New Research on Mice in Biomedical Research

Lisa R. Parker

“The Mouse in Biomedical Research” ebook is an important elaboration on the effects of a new drugs and different medical treatment on the genes of mice. This allows medical professionals to correctly prepare drugs for human beings, as genes of mice are remarkably similar to humans. Mice in biomedical research are being used to study the various illnesses and the possible treatments against these.

Strains of mice in biomedical research are found to display symptoms of Alzheimer’s disease, obesity, diabetes, cancer and other diseases affecting human beings. Annually, about 25 million mice are now being used in biomedical research. These mice are subjected to genetic modifications by their suppliers, based on which medical research is carried out.

There are several companies which supply mice and other lab animals for research basis, and while some operate on non-profit basis, others are profit oriented. A genetically altered mouse can cost a good sum of money, but getting it altered as per specific needs costs even more. To understand this better, the above mentioned ebook has been developed.

For biomedical researchers, it is certainly worth investing the money to get all the related information from a single source. All the information from the book can be accessed conveniently, either from home or on the go. This ebook on mice in biomedical research can be read with a laptop, tablet PC or a smartphone.

This book provides all the information on the history, biology and genomics of the laboratory mouse. It provides basic information on the use of mouse stocks and their maintenance. Genetics and haploid set of chromosomes of the mouse are covered in different chapters on various subjects like genetic nomenclature, gene mapping and cytogenetics. Maintenance of laboratory mice is described in chapters on breeding methods for various types of strains and stocks. These chapters also provide information on genetic monitoring.

The information on use of mice in biomedical research is provided under subjects like chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. Due to interplay of environmental chemical compounds and cell metabolism, genetic changes occur in DNA structure affecting one or more genes. These chemically fostered or induced mutations are known as chemical mutagenesis. Gene trapping involves an approach used to introduce insertional mutations across the haploid set on a mammalian chromosome. Pharmacogenetics refers to genetic differences in metabolic pathways. These differences can affect individual responses to drugs and hence can be used to study them in terms of both therapeutic and adverse effects on humans.

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